Inhalation imaging with oxygen-15 labeled carbon dioxide for detection and quantitation of left-to-right shunts.

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Inhalation imaging with oxygen-15 labeled carbon dioxide for detection and quantitation of left-to-right shunts.

Quantitation of left-to-right shunts was determined noninvasively from the pulmonary clearance pattern of inhaled 15oxygen-labeled carbon dioxide (C15O2). After a single breath inhalation of C15O2, counts over the lungs were obtained from sequential 0.5 sec positron camera images. In 21 patients without left-to-right shunts, counts declined exponentially due to the washout of C15O2 by the pulmo...

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Noninvasive detection and quantification of left-to-right shunts in children using oxygen-15 labeled carbon dioxide.

A method for the detection and quantification of left-to-right intracardiac shunts is described which utilizes a single breath inhalation of oxygen-15 labeled carbon dioxide (C15O2). The inhaled gas rapidly crosses the alveolar membrane and the oxygen-15 label is exchanged through the carbonate cycle to form oxygen-15 labeled water within the pulmonary capillary blood. Pulmonary indicator clear...

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Quantitation of left-to-right cardiac shunts with radionuclide angiography.

A quantitative radionuclide angiogram technique using an intravenous injection of technetium99m (Tc-99m) pertechnetate is described for quantitation of left-to-right shunts in the central circulation. Data analysis assumes exponential indicator clearance from normal cardiac chambers by dilution. A late prolongation of tracer disappearance compared to the initial clearance rate indicates an abno...

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Radionuclide quantitation of right-to-left intracardiac shunts in children.

A simple, noninvasive method for measurement of right-to-left intracardiac shunts would enhance the management of patients with congenital heart disease. This study describes application of data processing techniques used previously in dye-indicator curves to data recorded during the initial transit of radioactive bolus through the central circulation. Radionuclide angiocardiograms were perform...

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The krypton85 inhalation test for the detection of left-to-right shunts.

One of the primary reasons for performing cardiac catheterization in patients known to have, or suspected of having, congenital heart disease is to determine whether a left-to-right shunt is present and the site at which it enters the right side of the heart. Although a variety of techniques for the detection of such shunts has been developed (Wood et al., 1957, 1958; Zimmerman, 1959; Braunwald...

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ژورنال

عنوان ژورنال: Circulation

سال: 1977

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.56.4.632